Lactoferrin

Emma Davies
Nutritional Consultant


Tactical Support
A multifunctional protein that has several balancing and restorative roles in the body
Dose
250mg per IMMUNE tablet / 50mg per SNOOZE tablet
Game Changing
Lactoferrin is already present within the body, so Leapfrog IMMUNE works in synergy with our bodies’ own natural immune systems
Form
Bovine Lactoferrin (bLf) is lactoferrin sourced from cow’s milk. Its similarity to human milk (up to 75% homology) means it shares many of the same therapeutic benefits
Antimicrobial
prevents viruses and bacteria from entering healthy cells and replicating
Bacteriostatic
binds iron to itself, starving viruses and bacteria of the iron they need in order to survive and thrive
Bactericidal
binds to bacterial walls and kills bacteria
Stimulates innate immunity
enhances the body’s immune response & improves the activation of white blood cells that respond to viruses and bacteria
Anti-Inflammatory
prevents harmful immune and inflammatory responses
Immunomodulatory
stimulates the immune system to act against germs and moderates our response to infections (maintains immune homeostasis and prevents the immune system going into overdrive) Also, helps us recover more quickly from infection.
Gut Health
promotes the growth of selected probiotic strains
Facts & Figures
We are keeping up to speed with the research on lactoferrin. Here are some of the latest clinical studies, critically assessed by peers and published independently.
Effects of lactoferrin on infectious diseases in Japanese summer (2020)
- Design: Randomized, double-blinded, placebo-controlled trial
- Participants: 290
- Dose: 200mg or 600mg daily
- Duration: 3 months
- Results: In summer, the intake of lactoferrin – both 200mg and 600mg – attenuates infectious diseases, including summer colds.
Read Study here
In vitro antiviral activity of lactoferrin against human coronaviruses (2021)
- Design: In vitro
- Participants: –
- Dose: –
- Duration: –
- Results: Broad-spectrum antiviral activity against SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E in cell culture.
Read Study here
A review of several studies on lactoferrin for prevention of common viral infections (2014)
- Design: Questionnaire
- Participants: 398 women
- Dose: 600mg daily
- Duration: 3 months
- Results: Fewer colds and less cold-like symptoms
Read Study here
The clinical efficacy of bovine lactoferrin and IgF for the Common Cold (2013)
- Design: Double-blinded, placebo-controlled clinical trial
- Participants: 126
- Dose: 600mg daily
- Duration: 90 days
- Results: reduction in colds & cold-related symptoms.
Read Study here
A review of several studies on lactoferrin as an immune modulator and anti-viral agent (2019)
- Design: Reference 2002 study in Microbiology
- Participants: 8 males
- Dose: 100mg and then 200mg daily
- Duration: 21 days
- Results: T-cell activation & antioxidant status achieved
Read Study here
A study on the effects of lactoferrin on the immune system of healthy volunteers (1998)
- Design: Study
- Participants: 10 males
- Dose: 2g daily
- Duration: 4 weeks
- Results: Lactoferrin may help activate body’s defences.
Read Study here
A study of lactoferrin on sufferers of Alzheimer’s, a malfunction of the immune system (2019)
- Design: Study
- Participants: 50 (28 men and 22 women)
- Dose: 250mg daily
- Duration: 3 months
- Results: Significant enhanced cognitive function
Read Study here
A study on the immunoregulatory effects of lactoferrin taken by healthy individuals (1998)
- Design: Study
- Participants: 17
- Dose: 40mg
- Duration: 10 days
- Results: Lactoferrin may regulate immune parameters
Read Study here
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 (2021)
- Design: In vitro screening of 1,425 FDA-approved drugs & clinical compounds for their anti-viral efficacy against SARS-CoV-2
- Participants: –
- Dose: –
- Duration: –
- Results: Lactoferrin beat all other contenders (including remdesivir and hydroxychloroquine) to inhibit SARS-CoV-2 infection in all cell models with multiple modes of action, including blockage of virus attachment to cells.
Read Study here
Evaluating the in vitro efficacy of bovine lactoferrin products against SARS-CoV-2 variants of concern (2022)
- Design: Custom imaging & analysis of Lactoferrin’s efficacy against SARS-CoV-2 in vitro
- Participants: –
- Dose: –
- Duration: –
- Results: Lactoferrin shows potent efficacy across different viral strains including the South African B.1.351, UK B.1.1.7, Brazilian P.1, and Indian Delta variants. Also chewable lactoferrin tablets are shown to have equivalent potency to unformulated lactoferrin.
Read Study here
Effects of lactoferrin on sleep quality, mood states, and enteric environment in poor sleepers (2018)
- Design: Randomized, placebo-controlled, double-blind study
- Participants: 31 adults
- Dose: 270mg/day liposomal Lactoferrin
- Duration: 4 weeks
- Results: Lactoferrin supplementation may improve subjective sleepiness and fatigue on rising, nighttime sleep quality, depressed mood, and stool consistency.
Read Study here
Effects of Lactoferrin on Sleep Conditions in Children Aged 12–32 Months (2020)
- Design: Randomized, double-blind, placebo-controlled trial
- Participants: 101 infants
- Dose: 48 mg/day lactoferrin fortified formula
- Duration: 13 weeks
- Results: Lactoferrin may improve sleep condition, especially morning symptoms in children above one year of age.
Read Study here
Lactoferrin reduces the risk of respiratory tract infections (2021)
- Design: Meta-analysis of Randomised Controlled Trials
- Participants: –
- Dose: –
- Duration: –
- Results: The meta-analysis revealed significantly reduced odds of developing respiratory infections supplementing with Lactoferrin. It may also have a beneficial role in managing symptoms and recovery of patients suffering from RTIs and may have the potential for use as an adjunct in COVID-19.
Read Study here