Emma Davies
"Lactoferrin is a nutrient classically found in breast milk. It binds iron and is transferred via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has important immunological properties, and is both antibacterial and antiviral."
Tactical Support
Multifunctional protein that has several balancing and restorative roles in the body
The Game-Changing Nutrient
Lactoferrin is already present within the body, so Leapfrog IMMUNE works in synergy with our bodies’ own natural immune systems
Dose
250mg per IMMUNE tablet
50mg per SNOOZE tablet
Form
Bovine Lactoferrin (bLf) is lactoferrin sourced from cow’s milk. Its similarity to human milk (up to 75% homology) means it shares many of the same therapeutic benefits
Antimicrobial
Prevents viruses and bacteria from entering healthy cells and replicating. Binds to bacterial walls and kills bacteria
Iron-binding
Starves viruses and bacteria of the iron they need in order to survive and thrive. Facilitates iron transport across the blood brain barrier, optimising cognitive function
Enhances BDNF (Brain-Derived Neurotrophic Factor)
BDNF is crucial for learning, memory, and neuroplasticity. Lactoferrin may stimulate its production.
Stimulates Innate Immunity
Enhances the body’s immune response & improves the activation of white blood cells that respond to viruses and bacteria
Anti-Inflammatory
Prevents harmful immune and inflammatory responses
Immunomodulatory
Stimulates the immune system to act against germs and moderates our response to infections (maintains immune homeostasis and prevents the immune system going into overdrive) Also, helps us recover more quickly from infection
Support Gut-Brain Axis
Promotes the growth of selected probiotic strains
Facts & Figures
We are keeping up to speed with the research on Lactoferrin. Here are some of the latest clinical studies, critically assessed by peers and published independently.
-
- Design: Randomized, double-blinded, placebo-controlled trial
- Participants: 290
- Dose: 200mg or 600mg daily
- Duration: 3 months
- Results: In summer, the intake of lactoferrin – both 200mg and 600mg – attenuates infectious diseases, including summer colds.
Read Study here
-
- Design: In vitro
- Participants: –
- Dose: –
- Duration: –
- Results: Broad-spectrum antiviral activity against SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E in cell culture.
Read Study here
-
- Design: Questionnaire
- Participants: 398 women
- Dose: 600mg daily
- Duration: 3 months
- Results: Fewer colds and less cold-like symptoms
Read Study here
-
- Design: Double-blinded, placebo-controlled clinical trial
- Participants: 126
- Dose: 600mg daily
- Duration: 90 days
- Results: reduction in colds & cold-related symptoms.
Read Study here
-
- Design: Reference 2002 study in Microbiology
- Participants: 8 males
- Dose: 100mg and then 200mg daily
- Duration: 21 days
- Results: T-cell activation & antioxidant status achieved
Read Study here
-
- Design: Study
- Participants: 10 males
- Dose: 2g daily
- Duration: 4 weeks
- Results: Lactoferrin may help activate body’s defences.
Read Study here
-
- Design: A comprehensive review
- Participants: -
- Dose: -
- Duration: -
- Results: Lactoferrin can be recommended for humans subjected to prolonged stress, especially in high ambient temperatures (soldiers and emergency services), patients after surgery and accidents, physically active people and training athletes.
Read Study here
-
- Design: Single-dose administration crossover study
- Participants: 16 healthy women
- Dose: 800mg + soy milk
- Duration: One day
- Results: Following calculation tasks heart rate variability demonstrated an upregulation of parasympathetic and a downregulation of sympathetic nervous activities
Read Study here
-
- Design: Study
- Participants: 17
- Dose: 40mg
- Duration: 10 days
- Results: Lactoferrin may regulate immune parameters
Read Study here
-
- Design: In vitro screening of 1,425 FDA-approved drugs & clinical compounds for their anti-viral efficacy against SARS-CoV-2
- Participants: –
- Dose: –
- Duration: –
- Results: Lactoferrin beat all other contenders (including remdesivir and hydroxychloroquine) to inhibit SARS-CoV-2 infection in all cell models with multiple modes of action, including blockage of virus attachment to cells.
Read Study here
-
- Design: Meta-analysis of Randomised Controlled Trials
- Participants: –
- Dose: –
- Duration: –
- Results: The meta-analysis revealed significantly reduced odds of developing respiratory infections supplementing with Lactoferrin. It may also have a beneficial role in managing symptoms and recovery of patients suffering from RTIs and may have the potential for use as an adjunct in COVID-19.
Read Study here
-
- Design: Custom imaging & analysis of Lactoferrin’s efficacy against SARS-CoV-2 in vitro
- Participants: –
- Dose: –
- Duration: –
- Results: Lactoferrin shows potent efficacy across different viral strains including the South African B.1.351, UK B.1.1.7, Brazilian P.1, and Indian Delta variants. Also chewable lactoferrin tablets are shown to have equivalent potency to unformulated lactoferrin.
Read Study here
-
- Design: Randomized, placebo-controlled, double-blind study
- Participants: 31 adults
- Dose: 270mg/day liposomal Lactoferrin
- Duration: 4 weeks
- Results: Lactoferrin supplementation may improve subjective sleepiness and fatigue on rising, nighttime sleep quality, depressed mood, and stool consistency.
Read Study here
-
- Design: Randomized, double-blind, placebo-controlled trial
- Participants: 101 infants
- Dose: 48 mg/day lactoferrin fortified formula
- Duration: 13 weeks
- Results: Lactoferrin may improve sleep condition, especially morning symptoms in children above one year of age.
Read Study here
-
- Design: Study
- Participants: 50 (28 men and 22 women)
- Dose: 250mg daily
- Duration: 3 months
- Results: Significant enhanced cognitive function
Read Study here
-
- Design: Meta-analysis of Randomised Controlled Trials
- Participants: –
- Dose: –
- Duration: –
- Results: The meta-analysis revealed that Lactoferrin, a multifunctional protein with iron chelation ability, plays an important role in stabilizing essential iron metabolism in both extracellular and intracellular systems. Due to the wide spectrum that Lactoferrin possesses in the brain, Lactoferrin can also become a supportive molecule for the therapeutic agent against Parkinson's Disease
Read Study here
-
- Design: -
- Participants: –
- Dose: –
- Duration: –
- Results: Iron imbalance and oxidative stress are common among patients with neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, dementia, depression, and multiple sclerosis. As an endogenous iron-chelator, lactoferrin prevents iron accumulation and dopamine depletion in Parkinson's disease patients. Oral lactoferrin supplementation could modulate the p-Akt/PTEN pathway, reduce Aβ deposition, and ameliorate cognitive decline in Alzheimer's disease.
Read Study here
-
- Design: 8 arm radial maze test
- Participants: 51 male piglets
- Dose: 155 (low) or 285 mg kg-1day-1(high) from postnatal days 3 to 38
- Duration: 35 days
- Results: Results found that the piglets in the two lactoferrin groups learned faster than the control group in both the easy and difficult learning tests. The treatment group had faster learning ability than the control group and better long-term memory, of 3 hours and 40 minutes.
Read Study here
IN THE PRESS
"Leapfrog IMMUNE is one of the latest, greatest and safest supplements to have on your radar. Pop one tablet at the earliest sign of a sniffle and watch it sashay away."
”"With immunity high on the priority list, I can personally attest to the powers of Leapfrog IMMUNE… these delicious chewable tablets have helped pull us back from the brink on a number of occasions."
”“I have been taking on of these chewable tablets at the
slightest niggle of feeling under the weather to boost immunity and keep a cold at bay.”
