Emma Davies
"Lactoferrin is a natural protein your body has always produced - present in your tears, saliva, and the lining of your nose and gut, and found in colostrum and mother's milk. It's anti-viral, anti-bacterial, and iron-balancing. It supports cognitive clarity and memory. It stimulates bone formation, promotes good gut health and supports skin by reducing oxidative stress and inflammation. It's incredibly multi-tasking."
Tactical Support
A multifunctional protein that has several balancing and restorative roles in the body. Lactoferrin is formulated within Leapfrog IMMUNE, DAILY, SNOOZE and FOCUS
The Game-Changing Nutrient
Lactoferrin is already present within the body, so you are supplementing your body with a protein it recognises. That's why it works so powerfully
Dose
250mg per IMMUNE tablet
100mg per DAILY tablet
50mg per SNOOZE and FOCUS tablet
Form
Our lactoferrin is sourced from fresh cow’s milk. Its similarity to human milk (up to 75% homology) means it shares many of the same therapeutic benefits
Antimicrobial
Prevents viruses and bacteria from entering healthy cells and replicating. Binds to bacterial walls and kills bacteria
Iron-binding
Starves viruses and bacteria of the iron they need in order to survive and thrive. Facilitates iron transport across the blood brain barrier, optimising cognitive function
Enhances BDNF (Brain-Derived Neurotrophic Factor)
BDNF is crucial for learning, memory, and neuroplasticity. Lactoferrin may stimulate its production.
Stimulates Innate Immunity
Enhances the body’s immune response & improves the activation of white blood cells that respond to viruses and bacteria
Anti-Inflammatory
Prevents harmful immune and inflammatory responses
Immunomodulatory
Maintains immune homeostasis and prevents the immune system going into overdrive. Also, helps us recover more quickly from infection
Supports Gut Health
Promotes the growth of selected probiotic strains
Facts & Figures
We are keeping up to speed with the research on Lactoferrin. Here are some of the latest clinical studies, critically assessed by peers and published independently.
-
- Design: Review of several randomized, double-blinded, placebo-controlled trials
- Participants: -
- Dose: -
- Duration: -
- Results: This narrative review offers updated and comprehensive insights into
the available literature on lactoferrin biology, biological properties, and clinical utility.
.
Read Study here
-
- Design: Double-blind, placebo-controlled, parallel-group
- Participants: 97
- Dose: 200mg or 600mg daily
- Duration: 4 weeks
- Results: Both high- and low-dose Lf alteredex vivoimmune cell responses after 4 weeks. High-dose increased T-cell subsets, promoting adaptive immunity, and reduced systemic inflammation, while low-dose reduced proinflammatory and cytotoxic immune cells. High- and low-dose Lf supplements may have immunoceutical benefits in older adults.
Read Study here
-
- Design: Randomized, double-blinded, placebo-controlled trial
- Participants: 290
- Dose: 200mg or 600mg daily
- Duration: 3 months
- Results: In summer, the intake of lactoferrin – both 200mg and 600mg – attenuates infectious diseases, including summer colds.
Read Study here
-
- Design: In vitro
- Participants: –
- Dose: –
- Duration: –
- Results: Broad-spectrum antiviral activity against SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E in cell culture.
Read Study here
-
- Design: Metanalysis of 25 studies
- Participants: –
- Dose: –
- Duration: –
- Results: Findings show 200 mg Lf/d reduces systemic inflammation, while formulas containing 35–833 mg Lf/d may reduce RTI incidence in infants and children, suggesting improved immune function.
Read Study here
-
- Design: Questionnaire
- Participants: 398 women
- Dose: 600mg daily
- Duration: 3 months
- Results: Fewer colds and less cold-like symptoms
Read Study here
-
- Design: Double-blinded, placebo-controlled clinical trial
- Participants: 126
- Dose: 600mg daily
- Duration: 90 days
- Results: reduction in colds & cold-related symptoms.
Read Study here
-
- Design: Reference 2002 study in Microbiology
- Participants: 8 males
- Dose: 100mg and then 200mg daily
- Duration: 21 days
- Results: T-cell activation & antioxidant status achieved
Read Study here
-
- Design: Study
- Participants: 10 males
- Dose: 2g daily
- Duration: 4 weeks
- Results: Lactoferrin may help activate body’s defences.
Read Study here
-
- Design: A comprehensive review
- Participants: -
- Dose: -
- Duration: -
- Results: Lactoferrin can be recommended for humans subjected to prolonged stress, especially in high ambient temperatures (soldiers and emergency services), patients after surgery and accidents, physically active people and training athletes.
Read Study here
-
- Design: Single-dose administration crossover study
- Participants: 16 healthy women
- Dose: 800mg + soy milk
- Duration: One day
- Results: Following calculation tasks heart rate variability demonstrated an upregulation of parasympathetic and a downregulation of sympathetic nervous activities
Read Study here
-
- Design: Study
- Participants: 17
- Dose: 40mg
- Duration: 10 days
- Results: Lactoferrin may regulate immune parameters. In addition, the data suggest that bovine lactoferrin may be applied in clinic to improve the immune status of patients.
Read Study here
-
- Design: Review / Critical Discussion
- Participants: -
- Dose: -
- Duration: -
- Results: Lactoferrin has the potential to fill the void left by estrogen as a therapy that can inhibit bone resorption and stimulate bone formation in osteoporosis patients.
Read Study here
-
- Design: Review
- Participants: -
- Dose: -
- Duration: -
- Results: The aim of this review is to provide an overview of research regarding the role of lactoferrin in maintaining immune homeostasis, in particular as a mediator of immune responses to infectious assault, trauma and injury
Read Study here
-
- Design: A randomized, double-blind, placebo-controlled trial
- Participants: 164, aged 13-40
- Dose: -
- Duration: 3 months
- Results: A twice daily regimen of lactoferrin with vitamin E and zinc significantly reduced acne lesions in people with mild to moderate acne vulgaris.
Read Study here
-
- Design: In vitro screening of 1,425 FDA-approved drugs & clinical compounds for their anti-viral efficacy against SARS-CoV-2
- Participants: –
- Dose: –
- Duration: –
- Results: Lactoferrin beat all other contenders (including remdesivir and hydroxychloroquine) to inhibit SARS-CoV-2 infection in all cell models with multiple modes of action, including blockage of virus attachment to cells.
Read Study here
-
- Design: Meta-analysis of Randomised Controlled Trials
- Participants: –
- Dose: –
- Duration: –
- Results: The meta-analysis revealed significantly reduced odds of developing respiratory infections supplementing with Lactoferrin. It may also have a beneficial role in managing symptoms and recovery of patients suffering from RTIs and may have the potential for use as an adjunct in COVID-19.
Read Study here
-
- Design: Custom imaging & analysis of Lactoferrin’s efficacy against SARS-CoV-2 in vitro
- Participants: –
- Dose: –
- Duration: –
- Results: Lactoferrin shows potent efficacy across different viral strains including the South African B.1.351, UK B.1.1.7, Brazilian P.1, and Indian Delta variants. Also chewable lactoferrin tablets are shown to have equivalent potency to unformulated lactoferrin.
Read Study here
-
- Design: Randomized, placebo-controlled, double-blind study
- Participants: 31 adults
- Dose: 270mg/day liposomal Lactoferrin
- Duration: 4 weeks
- Results: Lactoferrin supplementation may improve subjective sleepiness and fatigue on rising, nighttime sleep quality, depressed mood, and stool consistency.
Read Study here
-
- Design: Randomized, double-blind, placebo-controlled trial
- Participants: 101 infants
- Dose: 48 mg/day lactoferrin fortified formula
- Duration: 13 weeks
- Results: Lactoferrin may improve sleep condition, especially morning symptoms in children above one year of age.
Read Study here
-
- Design: Study
- Participants: 50 (28 men and 22 women)
- Dose: 250mg daily
- Duration: 3 months
- Results: Significant enhanced cognitive function
Read Study here
-
- Design: Meta-analysis of Randomised Controlled Trials
- Participants: –
- Dose: –
- Duration: –
- Results: The meta-analysis revealed that Lactoferrin, a multifunctional protein with iron chelation ability, plays an important role in stabilizing essential iron metabolism in both extracellular and intracellular systems. Due to the wide spectrum that Lactoferrin possesses in the brain, Lactoferrin can also become a supportive molecule for the therapeutic agent against Parkinson's Disease
Read Study here
-
- Design: -
- Participants: –
- Dose: –
- Duration: –
- Results: Iron imbalance and oxidative stress are common among patients with neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, dementia, depression, and multiple sclerosis. As an endogenous iron-chelator, lactoferrin prevents iron accumulation and dopamine depletion in Parkinson's disease patients. Oral lactoferrin supplementation could modulate the p-Akt/PTEN pathway, reduce Aβ deposition, and ameliorate cognitive decline in Alzheimer's disease.
Read Study here
-
- Design: 8 arm radial maze test
- Participants: 51 male piglets
- Dose: 155 (low) or 285 mg kg-1day-1(high) from postnatal days 3 to 38
- Duration: 35 days
- Results: Results found that the piglets in the two lactoferrin groups learned faster than the control group in both the easy and difficult learning tests. The treatment group had faster learning ability than the control group and better long-term memory, of 3 hours and 40 minutes.
Read Study here
-
- Design: Open label pilot trial
- Participants: 21 rats
- Dose: 270 mg of L-bLF per day
- Duration: 7-21 days
- Results: Overall, it was found that prophylactic L-bLF supplementation
reduced neuroinflammation in rat hippocampi and improved sleep quality and jetlag in tour conductors (all
experimental protocols were approved by the Ethics Committee on Animal Care and Use of the RIKEN Center for Life Science Technologies (Approval No.: MA2007-01-22, Approval date: 4 July 2019)
Read Study here
IN THE PRESS
"Leapfrog IMMUNE is one of the latest, greatest and safest supplements to have on your radar. Pop one tablet at the earliest sign of a sniffle and watch it sashay away."
”"With immunity high on the priority list, I can personally attest to the powers of Leapfrog IMMUNE… these delicious chewable tablets have helped pull us back from the brink on a number of occasions."
”“I have been taking on of these chewable tablets at the
slightest niggle of feeling under the weather to boost immunity and keep a cold at bay.”
