The Science

Your lactoferrin baseline

The immune protein your body produces naturally, why your levels drop, and what happens when you top them back up.

Emma Davies
Emma Davies Leapfrog Nutritionist · 4 min read

Lactoferrin is a natural protein produced by your body. It is part of your immune system's first line of defence, present in your saliva, your airways, your gut lining, and virtually every surface where your body meets the outside world.

High lactoferrin levels can help your body to stay strong against illness and stress. But here's the thing: your body does not store it in reserve.

It produces lactoferrin continuously, because it uses lactoferrin continuously. And our modern lifestyle means most of us are permanently running low.

Lactoferrin is present across your body's mucosal surfaces

Your baseline is under pressure

Illness takes a toll. When your body fights infection, it burns through its available lactoferrin fast. And once that supply is spent, it takes time to replenish.

Stress, too, is a major drain on your lactoferrin levels. When we're under pressure, cortisol rises. Research has shown a direct inverse relationship between cortisol and lactoferrin levels: as one rises, the other falls.

Poor sleep, intense exercise, and ageing all have a similar effect. And as we get older, we need more lactoferrin to bolster our increasingly fragile immune system.

When we're healthy, low lactoferrin levels are manageable. We only notice when it's too late, and something breaks through.

Your levels change. Your need doesn't.

YOUR LEVELS Rested baseline After illness High stress Poor sleep YOUR NEED Age 20 Age 40 Age 60+

Illustrative of directional findings in published research. Your need for lactoferrin rises as the immune system it supports becomes less resilient with age.

Leapfrog IMMUNE
★★★★★

"So often I take things and don't feel the results, and with Leapfrog I really do. It's good to know that lactoferrin is natural. It is honestly the one thing I can pick up and say, 'This works.'"

Toni P.

Supplementing what your body already uses

Because lactoferrin is a protein your body already produces and already knows how to use, supplementing it is closer to replenishment than intervention. You are not introducing something foreign. You are topping up something your body is already running on.

Clinical research supports this. Studies show measurable reduction in the inflammatory marker IL-6 at around 200 mg per day, with meaningful outcomes emerging over weeks of consistent use. Practitioners recommend beginning supplementation 2 to 4 weeks before high-exposure periods and continuing for 8 to 12 weeks.

Power-up, or maintain

Power-up
When you need reinforcement
A concentrated dose to power up your defences during periods of challenge or exposure.
Maintain
Keep a high baseline
Take lactoferrin regularly, so your body's defences are never caught off guard. Consistent levels mean consistent protection.
Low Optimal Optimal Day 0 Week 2 Week 6 Week 12 With daily lactoferrin Without supplementation
Stephanie Drax, Founder of Leapfrog Remedies
Stephanie Drax Founder, Leapfrog Remedies

When a scientist first told me about lactoferrin, I found it hard to believe how many benefits it has. I did a deep dive into the research and found that it was backed up by thousands of peer-reviewed scientific studies.

It's a very expensive ingredient, but for the difference it can make to our wellbeing, it's tremendous value. It really works.

It's why so many of you get in touch with me every day, to tell me how it's made a real difference.

Built around this research

IMMUNE delivers 250 mg of lactoferrin, to supercharge your immunity

Leapfrog IMMUNE

Leapfrog IMMUNE

Chewable tablets combining lactoferrin with zinc and vitamin C. Designed to work at the mucosal surfaces where your body needs it most.

250 mg Lactoferrin Zinc Vitamin C
15 chewable tablets · Citrus flavour
Shop IMMUNE  →

From £34.99  ·  Subscribe and save 20%

  1. Lactoferrin presence in exocrine secretions: mucosal surfaces of respiratory, urogenital and intestinal tracts. MDPI, Nutrients.
  2. Independent glandular lactoferrin secretion confirmed in neutrophil-deficient patients. Journal of Allergy and Clinical Immunology.
  3. Lactoferrin in neutrophil secondary granules. MDPI, Molecules.
  4. Iron-binding affinity 300x greater than transferrin. ScienceDirect.
  5. Plasma lactoferrin elevation during acute infection. MDPI.
  6. Lactoferrin bridging innate and adaptive immune responses. Nature Reviews Immunology.
  7. Salivary lactoferrin and cortisol inverse correlation. Springer, European Journal of Applied Physiology.
  8. IL-6 reduction at ~200 mg/day lactoferrin. PubMed Central.
  9. Practitioner dosing guidance: 2 to 4 weeks pre-exposure, 8 to 12 weeks continuous. VitaLibrary.
  10. Colostrum lactoferrin concentration and infant immunity. PubMed Central.
Leapfrog IMMUNE
Leapfrog IMMUNE 250 mg Lactoferrin + Zinc + Vitamin C
★★★★★
Shop IMMUNE →